CGB8
Description
The CGB8 (chorionic gonadotropin subunit beta 8) is a protein-coding gene located on chromosome 19.
CGB8 encodes the beta subunit of human chorionic gonadotropin (hCG), a hormone crucial for pregnancy and maternal adaptation. hCG is a complex glycoprotein composed of two subunits: alpha and beta. The alpha subunit is common to other pituitary gonadotropins (LH, FSH, TSH), while the beta subunit is unique to hCG, conferring its receptor and biological specificity. CGB8's product plays a vital role in stimulating the ovaries to produce steroids necessary for maintaining pregnancy.
CGB8 is also known as -.
Associated Diseases
- Kallmann syndrome
- isolated congenital hypogonadotropic hypogonadism
- hypogonadotropic hypogonadism
- 46,XX testicular disorder of sex development
- partial androgen insensitivity syndrome
- 46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome
- male infertility with teratozoospermia due to single gene mutation
- 46,XY complete gonadal dysgenesis
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
- partial chromosome Y deletion
- congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency
- ring chromosome Y
- hypogonadotropic hypogonadism 23 with or without anosmia
- obesity due to congenital leptin deficiency
- isochromosomy Yp
- primary hypergonadotropic hypogonadism-partial alopecia syndrome
