CENPW
Description
The CENPW (centromere protein W) is a protein-coding gene located on chromosome 6.
CENPW is a component of the CENPA-NAC complex, which plays a crucial role in assembling kinetochore proteins, ensuring proper mitotic progression, and facilitating chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD complex, potentially contributing to the incorporation of newly synthesized CENPA into centromeres. CENPW is part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, unlike those containing CENPA. Additionally, CENPW is part of the heterotetrameric CENP-T-W-S-X complex, which binds and supercoils DNA, playing a critical role in kinetochore assembly. CENPW is essential for proper kinetochore assembly and function, acting as an inner kinetochore protein with many other proteins binding to it. CENPW is necessary for maintaining normal chromosome organization and proper progression through mitosis.
CENPW is also known as C6orf173, CENP-W, CUG2.
