CELA3A
Description
The CELA3A (chymotrypsin like elastase 3A) is a protein-coding gene located on chromosome 1.
Chymotrypsin-like elastase family member 3A is an enzyme encoded by the CELA3A gene in humans. Elastases are a subfamily of serine proteases that break down various proteins, including elastin. Humans possess six elastase genes, encoding proteins like elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has limited elastolytic activity. Similar to most human elastases, elastase 3A is secreted from the pancreas as a zymogen. Like trypsin, chymotrypsin, and kallikrein, it plays a digestive role in the intestine. Elastase 3A primarily cleaves proteins after alanine residues. It may also contribute to intestinal cholesterol transport and metabolism. Elastase 3A and 3B have been referred to as protease E and elastase 1.
CELA3A is also known as ELA3, ELA3A.
