CECR5-AS1
cecr5-as1: An Intriguing Long Non-Coding RNA with Diverse Roles in Disease
Introduction
cecr5-as1, also known as C-C chemokine receptor type 5 antisense RNA 1, is a long non-coding RNA (lncRNA) that has emerged as a key player in a wide range of biological processes. Its involvement in various diseases makes it a promising target for therapeutic interventions. This blog post delves into the description, associated diseases, statistics, references, and latest research findings on cecr5-as1.
Description
cecr5-as1 is a lncRNA located on chromosome 3p21.31. It spans approximately 10 kilobases and does not encode any proteins. Instead, it regulates gene expression by interacting with transcription factors, chromatin modifiers, and other RNA molecules.
Associated Diseases
cecr5-as1 has been implicated in several diseases, including:
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HIV-1 infection: cecr5-as1 is involved in the regulation of CCR5, a chemokine receptor used by HIV-1 to enter host cells. By modulating CCR5 expression, cecr5-as1 can influence HIV-1 replication and disease progression.
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Cancer: cecr5-as1 has been found to play a role in the development and progression of various cancers, such as lung cancer, breast cancer, and colon cancer. It can promote cancer cell proliferation, invasion, and metastasis.
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Immune disorders: cecr5-as1 is involved in regulating immune responses. Dysregulation of cecr5-as1 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus.
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Cardiovascular diseases: cecr5-as1 may contribute to the development of cardiovascular diseases by regulating inflammatory pathways and vascular smooth muscle cell function.
Did you Know ?
A study published in the journal "Nature Medicine" found that HIV-1 patients with high cecr5-as1 expression have a significantly lower viral load and a slower disease progression compared to patients with low cecr5-as1 expression. This suggests that cecr5-as1 may have therapeutic potential in HIV-1 infection.
