CDS1
Description
The CDS1 (CDP-diacylglycerol synthase 1) is a protein-coding gene located on chromosome 4.
CDS1 (Phosphatidate cytidylyltransferase 1) is an enzyme involved in the production of phosphatidylinositol, a crucial signaling molecule. It catalyzes the conversion of phosphatidic acid to CDP-diacylglycerol, a key precursor for phosphatidylinositol synthesis. CDS1 is localized to both the mitochondrial inner membrane and the endoplasmic reticulum. Two genes encoding this enzyme have been identified in humans: CDS1 on chromosome 4q21 and CDS2 on chromosome 20p13.
CDS1 catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), a key intermediate in the synthesis of phosphatidylglycerol, cardiolipin, and phosphatidylinositol. It exhibits minimal acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition. CDS1 plays a crucial role in regulating the growth of lipid droplets, which are storage organelles central to lipid and energy homeostasis. It positively regulates the differentiation and development of adipocytes.
CDS1 is also known as CDS 1.
Associated Diseases
- type 2 diabetes mellitus
- male infertility with teratozoospermia due to single gene mutation
- premature ovarian failure 12
- spermatogenic failure 65
- spermatogenic failure 72
- spermatogenic failure 18
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure, X-linked, 3
- spermatogenic failure 42
- spermatogenic failure 40
- spermatogenic failure 39
- spermatogenic failure 45
- spermatogenic failure 19
