CDK3
Description
The CDK3 (cyclin dependent kinase 3) is a protein-coding gene located on chromosome 17.
CDK3, also known as Cell division protein kinase 3, is an enzyme encoded by the CDK3 gene in humans. It has been suggested that CDK3 may be involved in cell cycle control, as it complements cdc28 mutants of Saccharomyces cerevisiae. CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin.
CDK3 is a serine/threonine-protein kinase that plays a key role in regulating the eukaryotic cell cycle, specifically in the transitions between G0 and G1 phases and G1 and S phases. It interacts with cyclin-C during interphase. CDK3 phosphorylates histone H1, ATF1, RB1, and CABLES1. Phosphorylation of ATF1 triggers its transactivation and transcriptional activities, promoting cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is essential for the G0-G1 transition. CDK3 likely promotes the G1-S transition by contributing to the activation of E2F1, E2F2, and E2F3 in a manner that doesn't depend on RB1.
CDK3 is also known as -.
Associated Diseases
- cancer
- metastatic malignant neoplasm
- nonpapillary renal cell carcinoma
- glioblastoma
- pachyonychia congenita
- breast cancer
