CDK2AP1
Description
The CDK2AP1 (cyclin dependent kinase 2 associated protein 1) is a protein-coding gene located on chromosome 12.
Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.
== Function == The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.
== Interactions == CDK2AP1 has been shown to interact with Cyclin-dependent kinase 2. It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.
== References ==
== External links == Human CDK2AP1 genome location and CDK2AP1 gene details page in the UCSC Genome Browser.
Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:20523938, PubMed:16428440, PubMed:28977666).
CDK2AP1 is also known as DOC1, DORC1, ST19, doc-1, p12DOC-1.
