CDC5L
Description
The CDC5L (cell division cycle 5 like) is a protein-coding gene located on chromosome 6.
CDC5L, also known as Cell division cycle 5-like protein, is a protein encoded by the CDC5L gene in humans. It shares similarities with the Schizosaccharomyces pombe cdc5 gene product, a cell cycle regulator important for G2/M transition. CDC5L acts as a positive regulator of cell cycle G2/M progression. It is also a key component of the non-snRNA spliceosome, essential for the second catalytic step of pre-mRNA splicing. CDC5L interacts with various proteins and is involved in the regulation of cell cycle progression and pre-mRNA splicing.
CDC5L is a DNA-binding protein that plays a crucial role in cell cycle control, potentially acting as a transcription activator. It is also a core component of the spliceosome, a complex involved in pre-mRNA splicing. CDC5L participates in the precatalytic, catalytic, and postcatalytic stages of spliceosomal complexes, contributing to the activation of pre-mRNA splicing. It is part of the PRP19-CDC5L complex, which is essential for spliceosome function and may be involved in the response to DNA damage. CDC5L is also a component of the minor spliceosome, responsible for splicing U12-type introns in pre-mRNAs. CDC5L forms a homodimer and interacts with various proteins, including DAPK3, PLRG1, Lodestar/TTF2, NIPP1/PPP1R8, and SCNM1. It also interacts with PRPF19 and BCAS2 through its C-terminus and with PRGL1 via its WD40 repeat domain. The interaction with PRGL1 is essential for mRNA splicing but not spliceosome assembly. CDC5L's interaction with PRPF19 through its N-terminus and with USB1 is also documented.
CDC5L is also known as CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- osteoarthritis
- congenital hydronephrosis
- congenital anomaly of kidney and urinary tract
