CDC16
Description
The CDC16 (cell division cycle 16) is a protein-coding gene located on chromosome 13.
CDC16 is a protein encoded by the CDC16 gene in humans. It is part of the Anaphase-Promoting Complex (APC) complex, which acts as a protein ubiquitin ligase. The APC complex controls the transition from mitosis to the next cell cycle phase by degrading specific proteins. CDC16 and two other APC proteins, CDC23 and CDC27, have a tetratricopeptide repeat (TPR), a protein domain that plays a role in protein interactions. Multiple versions of CDC16 are produced by alternative splicing, but they all encode the same protein. CDC16 interacts with other APC complex proteins like CDC27 and CDC20.
CDC16 is a component of the anaphase promoting complex/cyclosome (APC/C), a key regulator of cell cycle progression. The APC/C acts as an E3 ubiquitin ligase, targeting specific proteins for degradation, which helps control transitions between different phases of the cell cycle, particularly during mitosis and the G1 phase. The APC/C primarily mediates the formation of 'Lys-11'-linked polyubiquitin chains, leading to protein degradation, and also participates in the formation of 'Lys-48' and 'Lys-63' linked polyubiquitin chains to a lesser extent.
CDC16 is also known as ANAPC6, APC6, CDC16Hs, CUT9.
