CD101
Description
The CD101 (CD101 molecule) is a protein-coding gene located on chromosome 1.
CD101, also known as Immunoglobulin superfamily member 2 (IGSF2), is a human gene.
CD101 inhibits T-cell proliferation by multiple mechanisms, including:
- Blocking CD3-induced signaling pathways, inhibiting tyrosine kinases required for IL2 production and cellular proliferation.
- Inhibiting phospholipase C-gamma-1 (PLCG1) phosphorylation, thereby preventing CD3-induced changes in intracellular calcium levels.
- Preventing nuclear translocation of nuclear factor of activated T-cells (NFAT) to the nucleus.
- Promoting IL10 secretion by cutaneous dendritic cells, further inhibiting T-cell proliferation.
CD101 may also serve as a marker for CD4(+) CD56(+) leukemic tumor cells. These functions are supported by multiple studies.
CD101 is also known as EWI-101, IGSF2, V7.
Associated Diseases
- type 2 diabetes mellitus
- type 1 diabetes mellitus
- nonimmune chronic idiopathic neutropenia of adults
- X-linked severe congenital neutropenia
- neutropenia, severe congenital, 2, autosomal dominant
- neutropenia-monocytopenia-deafness syndrome
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency