CCNE1
Description
The CCNE1 (cyclin E1) is a protein-coding gene located on chromosome 19.
Cyclin E1, encoded by the CCNE1 gene, is a crucial component of the cell cycle machinery. It belongs to the cyclin family of proteins, characterized by their cyclical changes in abundance throughout the cell cycle. Cyclin E1 specifically forms a complex with CDK2, a kinase essential for transitioning cells from the G1 phase (growth) to the S phase (DNA replication). This complex ensures the proper timing and coordination of DNA replication. The levels of Cyclin E1 rise at the G1-S boundary and then decrease as cells progress through the S phase. Interestingly, overexpression of CCNE1 has been linked to tumorigenesis, potentially by contributing to chromosome instability. It also interacts with other proteins involved in cell cycle regulation, such as NPAT and UHRF2.
CCNE1 is also known as CCNE, pCCNE1.
