CCDC93
Description
The CCDC93 (coiled-coil domain containing 93) is a protein-coding gene located on chromosome 2.
CCDC93, also known as Coiled-coil domain-containing protein 93, is a protein encoded by the CCDC93 gene in humans. It is a component of the CCC complex, which plays a role in regulating the recycling of surface proteins, such as integrins, signaling receptors, and channels. This complex also interacts with other protein complexes, including SNX17, retriever, and WASH, to prevent the degradation of these proteins and promote their recycling back to the cell surface. CCDC93 is also involved in the trafficking of copper-containing ATP7A protein between the trans-Golgi network and vesicles at the cell periphery.
CCDC93 is a component of the CCC complex, which regulates the recycling of surface proteins like integrins, signaling receptors, and channels from endosomes back to the cell surface. This complex interacts with other protein complexes, including SNX17, retriever, and WASH, to prevent lysosomal degradation and promote recycling of various cargos such as integrins ITGA5:ITGB1. CCDC93 also plays a role in copper-dependent trafficking of the ATP7A protein between the trans-Golgi network and vesicles at the cell periphery. This function is proposed to rely on its association with the CCC complex, cooperation with the WASH complex on early endosomes, and interaction with WASHC2C.
CCDC93 is also known as -.
