CBY1
Description
The CBY1 (chibby 1, beta catenin antagonist) is a protein-coding gene located on chromosome 22.
CBY1 is a protein encoded by the CBY1 gene in humans. It interacts directly with β-catenin, an oncoprotein involved in cancer development. CBY1 inhibits β-catenin-mediated transcriptional activation by competing with transcription factors for binding to β-catenin. This prevents the oncogenic activity of β-catenin. Two isoforms of CBY1 have been identified. CBY1 interacts with several other proteins including β-catenin, CEP164, CIBAR1, and RAB8A.
CBY1 inhibits the Wnt/Wingless signaling pathway by binding to β-catenin and preventing its interaction with transcription factors (TCF/LEF), thus blocking β-catenin-mediated gene activation. It also regulates intracellular transport, particularly of polycystin-2 (PKD2), and potentially other proteins. CBY1 promotes the differentiation of both adipocytes and cardiomyocytes.
CBY1 is also known as C22orf2, CBY, Chibby1, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1.
