CBX6
Description
The CBX6 (chromobox 6) is a protein-coding gene located on chromosome 22.
CBX6 is a human gene encoding a protein known as chromobox protein homolog 6. It is part of a complex called PRC1-like, which plays a role in regulating gene expression during development. This complex helps to silence specific genes, including those involved in body development (Hox genes).
CBX6 is a component of the Polycomb group (PcG) multiprotein PRC1-like complex, a complex class essential for maintaining the transcriptionally repressive state of numerous genes, including Hox genes, throughout development. The PcG PRC1 complex functions through chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', resulting in heritable changes in chromatin expression. CBX6 may contribute to the target selectivity of the PRC1 complex by binding to specific regions of chromatin. Its recruitment to chromatin might occur independently of H3K27me3. CBX6 may have a PRC1-independent function in embryonic stem cells.
CBX6 is also known as -.
Associated Diseases
- endometrial cancer
- breast cancer
- nonpapillary renal cell carcinoma
- glycogen storage disease VI
- hyperinsulinism due to INSR deficiency
