CATSPER2 : cation channel sperm associated 2
CATSPER2: The Gene Responsible for Sperm Motility
Description:
The CATSPER2 gene, short for Calcium-Sensing Sperm-Specific Protein 2, holds the blueprint for the production of a crucial protein found in the tail or flagellum of sperm cells. This protein forms an essential part of a pore that enables the passage of calcium ions (Ca2+) across the sperm cell membrane. Calcium ions are indispensable for a specialized form of sperm motility called hyperactivation.
Associated Diseases:
Mutations in the CATSPER2 gene can lead to male infertility due to impaired sperm movement. These mutations can result in reduced or absent hyperactivation, hindering the sperm's ability to navigate the female reproductive tract and reach the egg for fertilization.
Did you Know ?
Research has shown that approximately 10-15% of male infertility cases can be attributed to mutations in CATSPER2 or other sperm-specific ion channel genes.
