TGFB2 : transforming growth factor beta 2
Description
The TGFB2 (transforming growth factor beta 2) is a protein-coding gene located on chromosome 1.
The TGFB2 gene provides instructions for producing the transforming growth factor beta-2 (TGFβ-2) protein, which is essential for development before birth and throughout life. TGFβ-2 binds to receptor proteins on the surface of cells, activating signaling pathways that control cell growth, division, differentiation, movement, and apoptosis. This protein functions within the TGF-β pathway and can suppress tumor formation by preventing uncontrolled cell growth. It plays roles in blood vessel formation, muscle tissue and fat development, wound healing, and immune system function. TGFβ-2 is particularly abundant in bone tissues, where it regulates growth, and in the extracellular matrix.
The Transforming growth factor beta-2 proprotein is a precursor to both the Latency-associated peptide (LAP) and the Transforming growth factor beta-2 (TGF-beta-2) chains. LAP acts as the regulatory subunit, while TGF-beta-2 is the active subunit of the mature TGF-beta-2 protein.
TGFB2 is also known as G-TSF, LDS4, TGF-beta2.
