TAB2
Description
The TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2) is a protein-coding gene located on chromosome 6.
TAB2, also known as MAP3K7-binding protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, is an adapter protein required to activate the JNK and NF-kappa-B signaling pathways. It specifically recognizes 'Lys-63'-linked polyubiquitin chains through its RanBP2-type zinc finger (NZF). TAB2 links MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains, forming a signaling complex that promotes autophosphorylation of MAP3K7/TAK1 and subsequent activation of the IKK core complex. It regulates IL1-mediated translocation of NCOR1 and is involved in heart development. TAB2 interacts with various proteins, including MAP3K7, TRAF6, RIPK1/RIP1, RIPK2, NCOR1, HDAC3, NUMBL, DYNC2I2, RBCK1, TRIM5, and TRIM38.
TAB2, also known as MAP3K7-binding protein 2, TAK1-binding protein 2, or TGF-beta-activated kinase 1-binding protein 2, acts as an adapter protein that plays a crucial role in activating the JNK and NF-kappa-B signaling pathways. This activation is mediated through the specific recognition of 'Lys-63'-linked polyubiquitin chains by TAB2's RanBP2-type zinc finger (NZF) domain. TAB2 further functions as a bridge, connecting MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains, ultimately promoting the formation of a large signaling complex. This complex facilitates the autophosphorylation of MAP3K7/TAK1, leading to the subsequent activation of the I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Additionally, TAB2 regulates the IL1-mediated translocation of NCOR1 out of the nucleus and is involved in heart development.
TAB2 is also known as CHTD2, MAP3K7IP2, TAB-2.
