RAF1 : Raf-1 proto-oncogene, serine/threonine kinase

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Description

The RAF1 gene encodes a protein kinase that plays a crucial role in the Ras/MAPK signaling pathway. This pathway is essential for regulating cell growth, proliferation, differentiation, and survival. RAF1 acts as a downstream effector of Ras, a small GTPase that is activated by various growth factors and other stimuli. Upon activation, RAF1 phosphorylates and activates MEK, which in turn activates ERK, a key transcription factor involved in cell cycle progression and gene expression. Mutations in the RAF1 gene can lead to uncontrolled cell growth and contribute to the development of cancer.

Associated Diseases

• Cancer (particularly melanoma, colorectal cancer, lung cancer, and thyroid cancer)
• Neurofibromatosis type 1
• Noonan syndrome

Did you know?

RAF1 was initially discovered in a study of viral oncogenes, where it was found to be the cellular homolog of the v-raf oncogene.