NR2F2
Description
The NR2F2 (nuclear receptor subfamily 2 group F member 2) is a protein-coding gene located on chromosome 15.
NR2F2 (nuclear receptor subfamily 2, group F, member 2), also known as COUP-TFII (chicken ovalbumin upstream promoter transcription factor 2), is a protein encoded by the NR2F2 gene in humans. COUP-TFII plays a critical role in controlling the development of various tissues and organs, including the heart, blood vessels, muscles, and limbs. The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation, while COUP-TFII represses the GR transcriptional activity. COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation. The structure of the COUP-TF2 ligand-binding domain (LBD) is known. Retinoic acid, although not at physiological concentrations, activates this receptor. COUP-TFII interacts with HDAC1, Lck, V-erbA-related gene, and nucleolin.
NR2F2 is a ligand-activated transcription factor. It is activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol, or progesterone. NR2F2 regulates the transcription of the apolipoprotein A-I gene. It binds to DNA site A and may be required to establish ovary identity during early gonad development.
NR2F2 is also known as ARP-1, ARP1, CHTD4, COUPTF2, COUPTFB, COUPTFII, NF-E3, SRXX5, SVP40, TFCOUP2.
