MYLK3

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Description

The MYLK3 (myosin light chain kinase 3) is a protein-coding gene located on chromosome 16.

Myosin light chain kinase 3, also known as MYLK3, is an enzyme encoded by the MYLK3 gene in humans. It functions by phosphorylating cardiac myosin heavy chains (encoded by MYH7B) and light chains (encoded by MYL2). This phosphorylation process enhances the force and rate of cross-bridge recruitment in cardiac myocytes, ultimately contributing to their contractile function.

This kinase phosphorylates MYL2 in vitro, promoting sarcomere formation in cardiomyocytes and enhancing cardiomyocyte contractility.

MYLK3 is also known as MLCK, MLCK2, caMLCK.

Associated Diseases

• left ventricular noncompaction
• dilated cardiomyopathy 1AA
• familial atrial fibrillation
• dilated cardiomyopathy 1I
• left ventricular noncompaction 10
• dilated cardiomyopathy 1KK
• dilated cardiomyopathy 1V
• sick sinus syndrome 2, autosomal dominant
• dilated cardiomyopathy 1GG
• atrial standstill
• hypertrophic cardiomyopathy 10
• cardiomyopathy, familial restrictive, 1
• long QT syndrome 15