MFAP5
Description
The MFAP5 (microfibril associated protein 5) is a protein-coding gene located on chromosome 12.
MFAP5 is a gene encoding a 25-kDa microfibril-associated glycoprotein rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions found in a related 31-kDa microfibril-associated glycoprotein (MFAP2). Despite these structural differences, MFAP5 shares a central region of 60 amino acids with MFAP2, including 7 aligned cysteine residues, suggesting some shared functionality. However, the structural distinctions indicate that MFAP5 likely possesses unique functions separate from MFAP2.
MFAP5 may play a role in hematopoiesis and potentially regulate growth factors or participate in cell signaling within the cardiovascular system to maintain large vessel integrity. It is a component of elastin-associated microfibrils.
MFAP5 is also known as AAT9, MAGP-2, MAGP2, MFAP-5, MP25.
