GATA5
Description
The GATA5 (GATA binding protein 5) is a protein-coding gene located on chromosome 20.
GATA5 is a gene that codes for a protein known as GATA-5. This protein is a transcription factor, which means it helps control the activity of other genes. GATA-5 has two GATA-type zinc fingers, which are protein structures that bind to DNA. GATA-5 binds to a protein called hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is crucial for activating the intestinal lactase-phlorizin hydrolase promoter. In other organisms, GATA-5-like proteins are involved in the development of heart muscle cells. GATA5 plays a crucial role in heart development by ensuring enough heart muscle precursor cells are produced. It also regulates other genes essential for heart formation. As pregnancy progresses, GATA5 helps specify the heart tissue that becomes the ventricles. Excessive GATA5 activity can lead to developmental problems.
GATA5 is a transcription factor required for cardiovascular development (PMID:23289003) and plays a role in smooth muscle cell diversity (by similarity). It binds to the CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PMID:25543888).
GATA5 is also known as CHTD5, GATAS, bB379O24.1.
Associated Diseases
- Familial atrial fibrillation
- Congenital heart defects, multiple types, 5
- Familial bicuspid aortic valve
- Tetralogy of Fallot
