TRDN
Description
The TRDN (triadin) is a protein-coding gene located on chromosome 6.
Triadin, also known as TRDN, is a human gene associated with the release of calcium ions from the sarcoplasmic reticulum, triggering muscular contraction through calcium-induced calcium release. Triadin is a multiprotein family, arising from different processing of the TRDN gene on chromosome 6. It is a transmembrane protein on the sarcoplasmic reticulum due to a well defined hydrophobic section and it forms a quaternary complex with the cardiac ryanodine receptor (RYR2), calsequestrin (CASQ2) and junctin proteins. The luminal (inner compartment of the sarcoplasmic reticulum) section of Triadin has areas of highly charged amino acid residues that act as luminal Ca2+ receptors. Triadin is also able to sense luminal Ca2+ concentrations by mediating interactions between RYR2 and CASQ2. Triadin has several different forms; Trisk 95 and Trisk 51, which are expressed in skeletal muscle, and Trisk 32 (CT1), which is mainly expressed in cardiac muscle. TRDN has been shown to interact with RYR1. Triadin is required to physically link the RYR2 and CASQ2 proteins, so that RYR2 channel activity can be regulated by CASQ2. The linkage of RYR2 with CASQ2 occurs via highly charged luminal sections of Triadin that are characterized as alternating positively and negatively charged amino acids, known as the KEKE motif. Luminal concentration levels of Ca2+ are sensed by CSQ, and this information is transmitted to RyR via Triadin.
TRDN is also known as CARDAR, CPVT5, TDN, TRISK.
Associated Diseases
- Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness
- Catecholaminergic polymorphic ventricular tachycardia
- Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy
- Romano-Ward syndrome
