PLD1

Description

The PLD1 gene, located on chromosome 11, encodes for phospholipase D1, a crucial enzyme involved in cell signaling. PLD1 catalyzes the hydrolysis of phosphatidylcholine, a major membrane phospholipid, to produce phosphatidic acid (PA). PA acts as a second messenger, participating in diverse cellular processes such as membrane trafficking, cytoskeletal organization, and cell growth. Its activity is regulated by various factors, including G-proteins, protein kinases, and phosphoinositides.

Associated Diseases

• Cancer (e.g., lung, breast, colon)
• Neurological disorders (e.g., Alzheimer's disease, Parkinson's disease)
• Cardiovascular disease (e.g., atherosclerosis)
• Diabetes
• Inflammation

Did you know?

PLD1 activity is tightly controlled by various cellular mechanisms, highlighting its role as a key regulator of signaling pathways.