HRAS
Description
The HRAS gene provides instructions for making a protein called H-Ras. This protein is a small GTPase, a type of protein that acts as a molecular switch, cycling between an active and inactive state. H-Ras plays a crucial role in cell signaling pathways, particularly those involved in cell growth, differentiation, and survival. It is activated by various external stimuli, such as growth factors, and transmits signals to the cell‘s nucleus, influencing gene expression and ultimately cellular behavior. Dysregulation of the HRAS gene can lead to uncontrolled cell growth and the development of various diseases.
Associated Diseases
- Cancer (e.g., colorectal cancer, lung cancer, bladder cancer)
- Noonan syndrome
- Cardiofaciocutaneous syndrome
- Neurofibromatosis type 1
Did you know?
Mutations in the HRAS gene are found in approximately 30% of all human cancers.
