CAPG
Description
The CAPG (capping actin protein, gelsolin like) is a protein-coding gene located on chromosome 2.
CAPG is a member of the gelsolin/villin family of actin-regulatory proteins. It controls actin-based motility in non-muscle cells by capping the barbed ends of actin filaments in a calcium and phosphoinositide-dependent manner. It does not sever preformed actin filaments. Alternative transcript variants have been observed but are not yet fully characterized.
CAPG is a calcium-sensitive protein that reversibly blocks the barbed ends of actin filaments. It does not sever preformed actin filaments. CAPG may be crucial for macrophage function and could regulate cytoplasmic and nuclear structures through interactions with actin. It may also bind to DNA.
CAPG is also known as AFCP, HEL-S-66, MCP.
Associated Diseases
- breast cancer
- nonpapillary renal cell carcinoma
- tarsal-carpal coalition syndrome
- isolated agammaglobulinemia
- common variable immunodeficiency
- hyper-IgM syndrome type 2
- neutrophil immunodeficiency syndrome
- immunodeficiency, common variable, 4
