GFI1
Description
The GFI1 (growth factor independent 1 transcriptional repressor) is a protein-coding gene located on chromosome 1.
Zinc finger protein Gfi-1 is a transcriptional repressor encoded by the GFI1 gene in humans. It plays a vital role in normal hematopoiesis. GFI1 interacts with PIAS3 and RUNX1T1.
GFI1 is a transcriptional repressor that is essential for hematopoiesis. It plays a role in cell-specific and development-specific functions. It binds to the promoter region of a large number of genes and is a component of several complexes involved in suppressing gene expression. These complexes recruit histone deacetylase (HDAC) to repress genes involved in blood cell development. GFI1 regulates neutrophil differentiation, promotes lymphoid cell proliferation, and is crucial for granulocyte development. It inhibits SPI1 transcriptional activity at macrophage-specific genes, suppressing macrophage differentiation and promoting granulocyte commitment. GFI1 also mediates, along with U2AF1L4, alternative splicing of CD45 and controls T-cell receptor signaling. It regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. GFI1 cooperates with CBFA2T2 in regulating ITGB1-dependent neurite growth. It controls cell cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1, through recruitment by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Finally, GFI1 is required for maintaining inner ear hair cells.
GFI1 is also known as GFI-1, GFI1A, SCN2, ZNF163.
Associated Diseases
- Neutropenia, nonimmune chronic idiopathic, of adults
- Autosomal dominant severe congenital neutropenia
- Neutropenia, severe congenital, 2, autosomal dominant
