CDH1

E-cadherin, linked to hereditary diffuse gastric cancer.

Associated Diseases

Hereditary Diffuse Gastric Cancer

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CDH1 mutations are rare and contribute to a small percentage of hereditary diffuse gastric cancer cases. The CDH1 gene, situated on chromosome 16q22.1, encodes the E-cadherin protein, a fundamental component of cell-cell adhesion in epithelial tissues. E-cadherin plays a pivotal role in maintaining tissue integrity and regulating cellular processes like proliferation and migration.


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