ATM
Description
The ATM gene plays a crucial role in maintaining genomic stability by initiating DNA repair mechanisms in response to double-strand breaks (DSBs). These breaks are highly damaging and can lead to mutations, cell death, and cancer. ATM acts as a sensor for DSBs, activating a signaling cascade that triggers cell cycle arrest, DNA repair, or apoptosis. This intricate process ensures the preservation of genetic information and safeguards against uncontrolled cell growth.
Associated Diseases
Did you know?
ATM gene mutations are responsible for the rare genetic disorder ataxia-telangiectasia, characterized by neurodevelopmental problems, immune deficiencies, and an increased risk of cancer.
