BRAF

The BRAF gene is a key player in cell signaling pathways, impacting various cellular processes and often implicated in cancer development. 

Associated Diseases

Adenocarcinoma of lung- somatic, Cardiofaciocutaneous syndrome, Colorectal cancer- somatic, LEOPARD syndrome 3, Melanoma- malignant and somatic, Nonsmall cell lung cancer- somatic, Noonan syndrome 7

Did you know

The BRAF gene, encoding the BRAF protein, is integral to cell signaling pathways that control cell growth, proliferation, and differentiation. It plays a pivotal role in transmitting signals from outside the cell to the cell nucleus, regulating essential cellular processes. Mutations in the BRAF gene can lead to dysregulated cell signaling, contributing to the development and progression of various cancers, including melanoma, colorectal cancer, and thyroid cancer. Notably, specific mutations in BRAF, such as the V600E mutation, are frequently observed in cancer and are targets for precision medicine treatments. Understanding the role of BRAF in cancer biology is critical for developing targeted therapies that can effectively inhibit aberrant BRAF signaling and improve patient outcomes. Additionally, BRAF testing is often performed in clinical settings to guide treatment decisions and personalize patient care.