CACYBP
Description
The CACYBP (calcyclin binding protein) is a protein-coding gene located on chromosome 1.
Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene. The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
== Protein Interactions == CACYBP has been shown to interact with SKP1A and SIAH1. The CacyBP/SIP complex instead, is known to be a part of stress respons, since it interacts with chaperone HSP90.
== References ==
== External links == Human CACYBP genome location and CACYBP gene details page in the UCSC Genome Browser.
CACYBP plays a role in the ubiquitination and degradation of target proteins in a calcium-dependent manner. It acts as a bridge within ubiquitin E3 complexes and is involved in the breakdown of beta-catenin.
CACYBP is also known as GIG5, PNAS-107, S100A6BP, SIP.
Associated Diseases
- keratoconus
- breast cancer
- urinary bladder carcinoma
- pachyonychia congenita
- Miyoshi myopathy
- cancer
- isolated asymptomatic elevation of creatine phosphokinase
