C8orf4
C8orf4: Exploring a Gene Linked to Multiple Cancers
Description
C8orf4 is a gene located on chromosome 8q24. It encodes a protein of unknown function and is involved in various cellular processes, including transcription, cell cycle regulation, and DNA repair.
Associated Diseases
C8orf4 mutations have been linked to several types of cancer, including:
- Breast cancer: Mutations in C8orf4 increase the risk of developing estrogen receptor-positive breast cancer.
- Colorectal cancer: C8orf4 mutations are associated with an increased risk of colorectal cancer in individuals with Lynch syndrome, a hereditary cancer syndrome.
- Endometrial cancer: Mutations in C8orf4 are associated with a higher risk of endometrial cancer, particularly in postmenopausal women.
- Pancreatic cancer: C8orf4 mutations have been found in a small percentage of pancreatic cancer patients and may contribute to tumor development and progression.
Did you Know ?
Approximately 5-10% of breast cancer cases are attributed to mutations in C8orf4, making it a significant genetic factor in this disease.
