C5orf66-AS2
c5orf66-as2: An Intriguing Long Non-Coding RNA with Emerging Health Implications
Introduction
In the realm of genetics, long non-coding RNAs (lncRNAs) are emerging as key players in regulating various biological processes. c5orf66-as2, a lncRNA located on chromosome 5, has captivated the attention of researchers for its potential implications in human health.
Description
c5orf66-as2 is a 2.2-kilobase lncRNA that does not code for any proteins. Instead, it exerts its effects by interacting with other molecules within the cell. Its primary function is to regulate gene expression by modulating the activity of transcription factors and other regulatory proteins.
Associated Diseases
Genetic alterations in c5orf66-as2 have been linked to various diseases, including:
- Cardiovascular Disease: c5orf66-as2 plays a role in endothelial cell function and blood vessel formation. Its dysregulation can contribute to atherosclerosis, hypertension, and coronary artery disease.
- Neurological Disorders: c5orf66-as2 is involved in brain development and function. Its alterations have been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
- Cancer: c5orf66-as2 has been found to be deregulated in several types of cancer, including breast, lung, and colorectal cancer. Its expression levels can influence tumor growth, invasion, and metastasis.
Did you Know ?
Studies have shown that genetic variations in c5orf66-as2 are associated with an increased risk of developing cardiovascular disease. For example, one study found that individuals with a certain c5orf66-as2 variant had a 2-fold higher risk of atherosclerosis compared to those without the variant.
