C2CD2L
Description
The C2CD2L (C2CD2 like) is a protein-coding gene located on chromosome 11.
C2CD2L, also known as C2 domain-containing protein 2-like or Transmembrane protein 24, is a lipid-binding protein responsible for transporting phosphatidylinositol from the endoplasmic reticulum to the cell membrane. This transport is crucial for maintaining the pool of phosphoinositides at the cell membrane, which are vital for cell signaling processes. Phosphoinositides are degraded during phospholipase C (PLC) signaling, and C2CD2L plays a role in replenishing these pools. C2CD2L localizes to the contact points between the endoplasmic reticulum and the cell membrane, tethering these two cellular compartments. When cytosolic calcium levels rise, C2CD2L undergoes phosphorylation at its C-terminus, causing it to dissociate from the cell membrane and halting phosphatidylinositol transport. This mechanism contributes to the coordination of calcium and phosphoinositide signaling. C2CD2L is also involved in regulating insulin secretion. By transporting phosphatidylinositol to the cell membrane, C2CD2L allows for the replenishment of PI(4,5)P2 pools, which in turn triggers calcium channel opening and prepares a new population of insulin granules for release.
C2CD2L is also known as DLNB23, TMEM24.
