C20orf78
c20orf78: A Gene with Intriguing Implications in Human Health
Description
c20orf78, also known as chromosome 20 open reading frame 78, is a protein-coding gene located on chromosome 20 in humans. The gene spans approximately 120 kilobases and encodes a protein of 399 amino acids. The c20orf78 protein is highly conserved across species, suggesting its crucial role in biological processes.
Associated Diseases
Dysregulation of the c20orf78 gene has been linked to a range of human diseases, including:
- Schizophrenia: Studies have identified associations between variations in c20orf78 and an increased risk of developing schizophrenia.
- Alzheimer's disease: Research suggests that reduced expression of c20orf78 may contribute to the neurodegenerative processes involved in Alzheimer's disease.
- Cancer: Aberrant expression of c20orf78 has been observed in various types of cancer, including breast cancer, prostate cancer, and lymphoma.
Did you Know ?
A genome-wide association study conducted in 2014 revealed that a common variant in the c20orf78 gene is associated with an increased risk of developing schizophrenia by approximately 15%.
