C1orf137
c1orf137: An Emerging Gene with Links to Disease
Description
c1orf137 (chromosome 1 open reading frame 137) is a gene located on chromosome 1 in humans. It encodes a protein of unknown function that has been implicated in several diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.
The c1orf137 protein is thought to be involved in cell signaling pathways and transcriptional regulation. It is highly expressed in the brain, heart, and skeletal muscle, suggesting that it plays an important role in these tissues.
Associated Diseases
Mutations in c1orf137 have been linked to several diseases, including:
- Cancer: c1orf137 mutations have been found in patients with breast cancer, lung cancer, and colorectal cancer. The mutations may lead to increased cell growth and proliferation, contributing to cancer development.
- Cardiovascular disease: Mutations in c1orf137 have been associated with an increased risk of heart failure and coronary artery disease. The mutations may impair the function of the heart muscle, leading to reduced pumping ability.
- Neurodegenerative disorders: Mutations in c1orf137 have been linked to an increased risk of Alzheimer's disease and Parkinson's disease. The mutations may lead to the accumulation of toxic proteins in the brain, causing neuronal damage and death.
Did you Know ?
Studies have shown that approximately 1% of the population carries a mutation in c1orf137. This suggests that the gene may play a significant role in human health and disease.
