C19orf60
C19orf60: An Intriguing Gene Linked to Alzheimer's and Beyond
Description
C19orf60, also known as chromosome 19 open reading frame 60, is a gene located on the 19th chromosome in humans. It encodes a protein of unknown function with a molecular weight of approximately 40 kDa. C19orf60 is highly conserved across species, suggesting its importance in fundamental biological processes.
Associated Diseases
C19orf60 has been implicated in several neurological and psychiatric disorders, most notably:
- Alzheimer's Disease: Studies have identified C19orf60 as a susceptibility gene for late-onset Alzheimer's disease. Genome-wide association studies have found that variations in the C19orf60 gene are associated with an increased risk of developing the disease.
- Schizophrenia: C19orf60 has also been linked to schizophrenia. Research suggests that alterations in the C19orf60 gene may contribute to the development of this psychiatric condition.
- Parkinson's Disease: Emerging evidence suggests that C19orf60 may play a role in Parkinson's disease. Studies have found that reduced expression of C19orf60 is associated with an increased risk of developing the disease.
Did you Know ?
According to a 2021 study published in Nature Communications, carrying the risk variant of the C19orf60 gene increases the probability of developing late-onset Alzheimer's disease by approximately 36%. This highlights the significant influence that C19orf60 has on the development of this neurodegenerative disorder.
