C15orf59
c15orf59: A Gene with Intriguing Roles in Health and Disease
Description
c15orf59, also known as chromosome 15 open reading frame 59, is a gene located on the long arm of chromosome 15 in humans. It encodes a protein of 278 amino acids involved in various biological processes, including cellular signaling, gene regulation, and protein translation.
Associated Diseases
c15orf59 has been implicated in the development of several diseases, including:
Neurodegenerative Disorders: Mutations in c15orf59 have been linked to familial cases of frontotemporal dementia (FTD), a brain condition characterized by progressive degeneration of the frontal and temporal lobes.
Mental Health Disorders: Altered c15orf59 expression has been observed in individuals with bipolar disorder and schizophrenia. The gene is thought to play a role in regulating brain circuits involved in mood and thought processing.
Cancer: Overexpression of c15orf59 has been found in certain types of cancer, such as breast cancer and lung cancer. It is believed to promote cancer cell growth and metastasis.
Other Diseases: c15orf59 mutations have also been associated with cerebral palsy and intellectual disability.
Did you Know ?
Research has shown that one in every 1,000 people worldwide carries a mutation in the c15orf59 gene. This mutation increases the risk of developing neurodegenerative disorders, particularly FTD.
