C11orf63
c11orf63: A Gene Linked to Neurodegenerative Disorders
Description
c11orf63 is a gene located on chromosome 11 in humans. It is responsible for coding a protein called chromosome 11 open reading frame 63 (C11orf63). This protein is believed to be involved in regulating gene expression and other cellular processes. Mutations in the c11orf63 gene have been linked to several neurodegenerative diseases.
Associated Diseases
- Amyotrophic lateral sclerosis (ALS): ALS is a fatal neurodegenerative disease that affects motor neurons, the cells that control muscle movement. Mutations in c11orf63 have been found in approximately 4% of ALS cases.
- Frontotemporal dementia (FTD): FTD is a group of neurodegenerative disorders that affect the frontal and temporal lobes of the brain. Mutations in c11orf63 have been found in approximately 10% of FTD cases.
- Alzheimer's disease (AD): AD is the most common form of dementia, affecting millions of people worldwide. While mutations in c11orf63 are not a major cause of AD, they have been found in a small percentage of cases.
Did you Know ?
According to a study published in the journal Nature Genetics, mutations in the c11orf63 gene are the most common genetic cause of familial ALS, accounting for approximately 20% of cases.
