BZW2
Description
The BZW2 (basic leucine zipper and W2 domains 2) is a protein-coding gene located on chromosome 7.
BZW2, also known as Basic Leucine Zipper W2 Domain-Containing Protein 2, is a eukaryotic translation factor found in various species, including bacteria. In animals, BZW2 resides in the cytoplasm and is expressed throughout the body, with higher levels in the heart, placenta, skeletal muscle, and hippocampus. Increased BZW2 expression in various cancers is linked to greater severity and mortality. It has been found to interact with SARS-CoV-2. BZW2 is located on chromosome 7, spanning 60,389 base pairs with 12 exons.
BZW2 acts as a translation initiation regulator, specifically repressing translation that starts at non-AUG codons, including repeat-associated non-AUG (RAN) translation. It achieves this by competitively inhibiting the function of eukaryotic translation initiation factor 5 (EIF5). BZW2 improves the accuracy of translation initiation by blocking EIF5-dependent translation from non-AUG codons. This occurs through competition with EIF5 for binding to EIF2S2 within the 43S pre-initiation complex (PIC), a process that relies on EIF3C binding.
BZW2 is also known as 5MP1, HSPC028, MST017, MSTP017.
Associated Diseases
- Alzheimer disease
- hereditary hyperferritinemia with congenital cataracts
- hyperinsulinism due to HNF1A deficiency
- galactokinase deficiency
- hemochromatosis type 5
- glycogen storage disease VI
