BZW1
Description
The BZW1 (basic leucine zipper and W2 domains 1) is a protein-coding gene located on chromosome 2.
BZW1 is a human protein encoded by the BZW1 gene and localized in the nucleus. It possesses RNA and cadherin binding capabilities. It has been linked to salivary gland carcinoma and eastern equine encephalitis. BZW1 interacts with PSTPIP1 and CDC5L.
This protein acts as a translation initiation regulator, repressing the initiation of translation from non-AUG start codons within repetitive sequences (RAN translation). It likely achieves this by competitively inhibiting the function of eukaryotic translation initiation factor 5 (eIF5). Additionally, it enhances the transcription of the histone H4 gene, although it doesn't appear to bind DNA directly.
BZW1 is also known as 5MP2, BZAP45, Nbla10236.
Associated Diseases
- cancer
- cochleosaccular degeneration-cataract syndrome
- male infertility with teratozoospermia due to single gene mutation
- hypergonadotropic hypogonadism-cataract syndrome
- deafness-infertility syndrome
- spermatogenic failure 65
- spermatogenic failure 72
- spermatogenic failure 18
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure, X-linked, 3
