BYSL
Description
The BYSL (bystin like) is a protein-coding gene located on chromosome 6.
Bystin is a protein produced by the BYSL gene in humans. It exists as two transcripts in SNG-M and HT-H cells. Bystin binds to trophinin and tastin, and this binding is strengthened by the presence of cytokeratins 8 and 18. In HT-H cells, bystin, trophinin, tastin, and cytokeratins colocalize, suggesting they form a complex in trophectoderm cells during implantation. Trophinin and bystin are found in the placenta from week six of pregnancy, specifically in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. Their levels decrease and disappear from placental villi after week 10. Bystin has been shown to interact with TROAP.
The BYSL gene encodes a protein involved in the processing of the 20S pre-rRNA precursor and the formation of 40S ribosomal subunits. It is also thought to play a role in regulating cell adhesion during the implantation of human embryos, possibly through its interaction with trophinin.
BYSL is also known as BYSTIN, Enp1.
