BTG1
Description
The BTG1 (BTG anti-proliferation factor 1) is a protein-coding gene located on chromosome 12.
BTG1 is a human protein encoded by the BTG1 gene. It is a member of a family of antiproliferative genes that negatively regulate cell proliferation. Its expression is highest during the G0/G1 phases of the cell cycle and decreases as cells progress through G1. BTG1 has been implicated in B-cell chronic lymphocytic leukemia due to its involvement in a chromosomal translocation. Mutations in BTG1 have also been linked to diffuse large B-cell lymphoma. Recent research suggests that BTG1 is essential for the proliferation and expansion of stem cells in the adult brain, specifically in the dentate gyrus and subventricular zone. It helps to maintain the quiescence of adult neural stem cells, preventing their depletion.
BTG1 is also known as APRO2.
