BRD8
Description
The BRD8 (bromodomain containing 8) is a protein-coding gene located on chromosome 5.
Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene. The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.
== Interactions == BRD8 has been shown to interact with Thyroid hormone receptor beta and Retinoid X receptor alpha.
== References ==
== External links == Human BRD8 genome location and BRD8 gene details page in the UCSC Genome Browser. Human SMAP2 genome location and SMAP2 gene details page in the UCSC Genome Browser.
BRD8 may function as a coactivator in transcriptional activation initiated by hormone-activated nuclear receptors. Its isoform 2 specifically enhances transcriptional activation driven by the receptors AR/DHTR, ESR1/NR3A1, RXRA/NR2B1, and THRB/ERBA2. At least isoforms 1 and 2 are part of the NuA4 histone acetyltransferase (HAT) complex, which plays a crucial role in activating select genes primarily through the acetylation of nucleosomal histones H4 and H2A. This acetylation can alter nucleosome-DNA interactions and facilitate the interaction of modified histones with other proteins that positively regulate transcription. The NuA4 complex is thought to be essential for activating transcriptional programs linked to oncogene and proto-oncogene-mediated growth induction, tumor suppressor-mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex may also directly participate in DNA repair when recruited to sites of DNA damage. It is also a component of a SWR1-like complex that specifically removes histone H2A.Z/H2AZ1 from the nucleosome.
BRD8 is also known as SMAP, SMAP2, p120.
