BMP5
Description
The BMP5 (bone morphogenetic protein 5) is a protein-coding gene located on chromosome 6.
BMP5 is a protein encoded by the BMP5 gene in humans. It belongs to the TGFβ superfamily, known for its role in bone and cartilage development. BMP5 may be involved in certain cancers. It is inhibited by chordin and noggin. BMP5 is expressed in the trabecular meshwork and optic nerve head, potentially playing a role in their development and function. It is also expressed in the lung and liver.
BMP5 is a growth factor belonging to the TGF-beta superfamily. It plays crucial roles in various developmental processes, including cartilage and bone formation, as well as neurogenesis. BMP5 initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. This activates BMPR1A to phosphorylate SMAD1/5/8, which then translocate to the nucleus, acting as activators or repressors of gene transcription. BMP5 can also signal through non-canonical pathways, such as the MAPK p38 signaling cascade, promoting chondrogenic differentiation. BMP5 promotes the expression of HAMP, but this is repressed when BMP5 interacts with ERFE.
BMP5 is also known as -.
