BIRC6
Description
The BIRC6 (baculoviral IAP repeat containing 6) is a protein-coding gene located on chromosome 2.
BIRC6, encoded by the BIRC6 gene, is a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. It inhibits apoptosis by facilitating the degradation of apoptotic proteins through ubiquitination. BIRC6 interacts with KIF23 and is implicated in various cancers, including leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and others.
BIRC6 is an anti-apoptotic protein that regulates cell death by controlling caspases and acting as an E3 ubiquitin-protein ligase. It has a unique ubiquitin conjugation system, combining ubiquitin conjugating (E2) and ubiquitin ligase (E3) activity in a single polypeptide, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. It acts as an inhibitor of CASP3, CASP7, and CASP9. It plays a vital role in the final stages of cytokinesis, ensuring proper vesicle targeting to the abscission site, maintaining the integrity of the midbody and midbody ring, and regulating its striking ubiquitin modification.
BIRC6 is also known as APOLLON, BRUCE.
