BIN2
Description
The BIN2 (bridging integrator 2) is a protein-coding gene located on chromosome 12.
BIN2 promotes cell movement and migration, likely through interactions with the cell membrane and podosome proteins that connect to the cell's internal scaffolding. It also alters the shape of the cell membrane, forming tube-like structures, and plays a role in the formation of podosomes, which are small structures involved in cell adhesion and migration. BIN2 has been found to inhibit the process of phagocytosis, where cells engulf and break down particles.
BIN2 is also known as BRAP-1.
Associated Diseases
- cancer
- beta-thalassemia-X-linked thrombocytopenia syndrome
- thrombocytopenia 4
- alpha-thalassemia-myelodysplastic syndrome
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin D disease
- macrothrombocytopenia, isolated, 2, autosomal dominant
- platelet-type bleeding disorder 10
- platelet-type bleeding disorder 15
- delta-beta-thalassemia
- thrombocytopenia 2
- dominant beta-thalassemia
