BEX1
Description
The BEX1 (brain expressed X-linked 1) is a protein-coding gene located on chromosome X.
Protein BEX1, also known as brain-expressed X-linked protein 1, is a protein that in humans is encoded by the BEX1 gene.
BEX1 is a signaling adapter molecule that participates in the p75NTR/NGFR signaling pathway. It plays a role in both cell cycle progression and neuronal differentiation, acting as an inhibitor of neuronal differentiation in response to nerve growth factor (NGF). BEX1 may function as a bridge between cell cycle regulation and neurotrophic factor signaling, potentially acting as an upstream regulator of receptor signaling and coordinating cellular responses to external stimuli with internal cellular conditions. In the absence of reductive stress, BEX1 serves as a pseudosubstrate for the CRL2(FEM1B) complex, associating with FEM1B through zinc binding. This interaction prevents FEM1B from associating with its target substrates.
BEX1 is also known as BEX2, HBEX2, HGR74-h.
Associated Diseases
- retinitis pigmentosa
- snowflake vitreoretinal degeneration
- Coats disease
- birdshot chorioretinopathy
- cataract 50 with or without glaucoma
- X-linked retinoschisis
- X-linked retinal dysplasia
- isolated ectopia lentis
- megalocornea
- Wagner disease
- aniridia
- exudative vitreoretinopathy 2, X-linked
