BACH1
Description
The BACH1 (BTB domain and CNC homolog 1) is a protein-coding gene located on chromosome 21.
BACH1 is a human protein encoded by the BACH1 gene. It is a transcription factor belonging to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). Unlike typical CNC-bZip family members, BACH1 contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains that facilitate protein-protein interactions and oligomer formation. The protein's C-terminus is a leucine zipper of the bzip_maf family. When BACH1 forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE), leading to transcriptional repression. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of the BACH1 gene overlap with some exons from the C21orf41 gene, which is transcribed in the opposite direction but does not seem to encode a protein.
BACH1 is also known as BACH-1, BTBD24.
