ATP6V0B
Description
The ATP6V0B (ATPase H+ transporting V0 subunit b) is a protein-coding gene located on chromosome 1.
The ATP6V0B gene encodes a component of the vacuolar ATPase (V-ATPase) enzyme, which is essential for acidifying various intracellular compartments in eukaryotic cells. V-ATPase is composed of two domains: a cytosolic V1 domain and a transmembrane V0 domain. ATP6V0B is part of the transmembrane V0 domain. This enzyme is involved in various intracellular processes, including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Different isoforms of V1 and V0 subunits are encoded by multiple genes and splice variants. ATP6V0B is the human counterpart of the yeast VMA16 protein.
ATP6V0B is also known as ATP6F, HATPL, VMA16.
